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  1. Design and conduct of the activated protein C and corticosteroids for human septic shock (APROCCHSS) trial

    … protein C and corticosteroids for human septic shock (APROCCHSS) trial … Bellissant, Eric The APROCCHSS Investigators for the TRIGGERSEP Network …

    10/02/2021 - 10:12

  2. Erratum to: Design and conduct of the activated protein C and corticosteroids for human septic shock (APROCCHSS) trial

    … protein C and corticosteroids for human septic shock (APROCCHSS) trial … Bellissant, Eric The APROCCHSS Investigators for the TRIGGERSEP Network …

    10/02/2021 - 10:12

  3. Clinical pharmacokinetics of 3-h extended infusion of meropenem in adult patients with severe sepsis and septic shock: implications for empirical therapy against Gram-negative bacteria

    … inhibitory concentration (MIC) of the pathogen for at least 40% of the dosing interval (fT > MIC > 40). We aimed to determine whether a 3-h extended infusion (EI) of meropenem achieves fT > MIC > 40 on the first and third days of therapy in patients with …

    10/02/2021 - 10:06

  4. Optimizing high-flow nasal cannula flow settings in adult hypoxemic patients based on peak inspiratory flow during tidal breathing

    … an F_IO_2 at 0.62 (0.16) to obtain an SpO_2/F_IO_2 of 160 (40). Mean PTIF was 34 (9) L/min. An increase in HFNC flows … PTIF values in most patients with AHRF were between 30 and 40 L/min. We observed improvement in oxygenation with HFNC … in patients with AHRF would be to initiate HFNC flow at 40 L/min and titrate the flow based on improvement in ROX …

    05/08/2022 - 12:04

  5. Treatment intensity, age and outcome in medical ICU patients: results of a French administrative database

    … increased from 13 % for the younger patients (age < 40 years) to 38 % for the older patients … age-related points) increased only from 36 (age < 40 years) to 43 (age ≥ 80). Hospital mortality …

    05/08/2022 - 12:11

  6. Frequency and prognostic impact of basic critical care echocardiography abnormalities in patients with acute respiratory distress syndrome

    … abnormalities (left ventricular ejection fraction < 40% and severe ACP) with ICU/hospital mortality and … 26.5% ICU mortality; 32.1% hospital mortality), 94 (40.2%) had at least one major BCCE-detected abnormality. The … (28.2%), followed by left ventricular ejection fraction < 40% (16.2%). On multivariate analysis, only severe ACP …

    10/02/2021 - 10:11

  7. Assessment of sepsis-induced immunosuppression at ICU discharge and 6 months after ICU discharge

    … and 6 months after ICU discharge Results A total of 40 patients were enrolled during their ICU stay: 21 males … ICU length of stay was 11 days (IQR 7–24). Among these 40 patients, 33 were studied at ICU discharge and 15 were …

    10/02/2021 - 10:11

  8. Association between potassium concentrations, variability and supplementation, and in-hospital mortality in ICU patients: a retrospective analysis

    Association between potassium concentrations, variability and supplementation, and in-hospital mortality in ICU patients: a retrospective analysis Auteur(s) …

    10/02/2021 - 10:08

  9. Impact of a high loading dose of amikacin in patients with severe sepsis or septic shock

    … 80 mg/L, and >80 mg/L in 20 (18.2%), 46 (41.8%) and 44 (40%) of the 110 selected patients, respectively. Mortality rate was 40, 28.3 and 56.8% in the groups of patients with C …

    10/02/2021 - 10:12

  10. Predictors of successful separation from high-flow nasal oxygen therapy in patients with acute respiratory failure: a retrospective monocenter study

    …  < 0.0001. Fraction of inspired oxygen (FiO_2) ≤ 40% and a respiratory rate-oxygenation (ROX) index … of 85% and 84%, respectively Conclusions FiO_2 ≤ 40% and ROX index ≥ 9.2 were two predictors of …

    10/02/2021 - 10:08