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  1. Risks of bleeding and thrombosis in intensive care unit patients with haematological malignancies

    … (57%) had at least one bleeding episode in ICU; they bled for 3 (2–6) days and most often from lower and upper …

    10/02/2021 - 10:11

  2. My patient has received fluid. How to assess its efficacy and side effects?

    My patient has received fluid. How to assess its efficacy and side … the kidney perfusion improvement. Even if oxygen delivery has increased with fluid, the increase in oxygen consumption … did not improve, one should check that cardiac output has actually increased with fluid administration. To assess …

    10/02/2021 - 10:09

  3. Lung recruitment: What has computed tomography taught us in the last decade?

    Lung recruitment: What has computed tomography taught us in the last decade? … lung imaging technique, through the years, CT scan has significantly improved our knowledge of the … The application of lung CT in the early phase of ARDS has led to changes in the clinical management in up of …

    10/02/2021 - 10:08

  4. Effects of positive end-expiratory pressure strategy in supine and prone position on lung and chest wall mechanics in acute respiratory distress syndrome

    … In acute respiratory distress syndrome (ARDS) patients, it has recently been proposed to set positive end-expiratory … on the measurement of absolute esophageal pressure (Pes), has been used in supine position (SP) and has not been investigated in prone position (PP). Our …

    10/02/2021 - 10:09

  5. Sleeping on a problem: the impact of sleep disturbance on intensive care patients - a clinical review

    … is commonly encountered amongst intensive care patients and has significant psychophysiological effects, which protract … sleep physiology and the impact that sleep disturbance has on patient psychophysiological recovery, and the contribution that the clinical environment has on intensive care patients’ sleep. …

    05/08/2022 - 12:11

  6. Cytokine removal in human septic shock: Where are we and where are we going?

    … international awareness. As a consequence, much effort has focused on alternative treatment strategies in an effort … blood purification therapies to improve immune homeostasis has been suggested as one such method, but these approaches, … to date. More recently, the use of sorbent technologies has attracted much attention. These adsorbers are highly …

    10/02/2021 - 10:08

  7. Role of albumin in the preservation of endothelial glycocalyx integrity and the microcirculation: a review

    … as a mechanosensor for hemodynamic shear stresses; it also has antithrombotic and anti-inflammatory functions. Plasma … addition, albumin transports sphingosine-1-phosphate which has protective endothelial effects, acts as a free radical scavenger, and has immunomodulatory and anti-inflammatory effects. This …

    10/02/2021 - 10:05

  8. Adsorption therapy in critically ill with septic shock and acute kidney injury: a retrospective and prospective cohort study

    … Abstract Background Haemoadsorption has been described as an effective way to control increased … shock patients. No prospective or randomised clinical study has yet confirmed these results. However, no study has yet prospectively specifically investigated patients in …

    10/02/2021 - 10:05

  9. Prediction of fluid responsiveness: an update

    … taken lightly. The risk of overzealous fluid administration has been clearly established. Moreover, volume expansion … pressure as well as other “static” markers of preload has been used for decades, but they are not reliable. Robust … used. More recently, the end-expiratory occlusion test has been described, which is easily performed in ventilated …

    10/02/2021 - 10:12

  10. The accuracy of presepsin for the diagnosis of sepsis from SIRS: a systematic review and meta-analysis

    … Background Sepsis is a common condition that has a high mortality and morbidity that need prompt … patients with sepsis and its diagnostic superiority has been confirmed by several preliminary studies. The aim … with no significant heterogeneity Conclusions Presepsin has moderate diagnostic capacity for the detection of …

    05/08/2022 - 12:11