21/03/2018

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Abstract
Background
The majority of critically ill patients do not suffer from acute respiratory distress syndrome (ARDS). To improve the treatment of these patients, we aimed to identify potentially modifiable factors associated with outcome of these patientsMethods
The PRoVENT was an international, multicenter, prospective cohort study of consecutive patients under invasive mechanical ventilatory support. A predefined secondary analysis was to examine factors associated with mortality. The primary endpoint was all-cause in-hospital mortalityResults
935 Patients were included. In-hospital mortality was 21%. Compared to patients who died, patients who survived had a lower risk of ARDS according to the ‘Lung Injury Prediction Score’ and received lower maximum airway pressure ( P _max), driving pressure (Δ P ), positive end-expiratory pressure, and FiO_2 levels. Tidal volume size was similar between the groups. Higher P _max was a potentially modifiable ventilatory variable associated with in-hospital mortality in multivariable analyses. Δ P was not independently associated with in-hospital mortality, but reliable values for Δ P were available for 343 patients only. Non-modifiable factors associated with in-hospital mortality were older age, presence of immunosuppression, higher non-pulmonary sequential organ failure assessment scores, lower pulse oximetry readings, higher heart rates, and functional dependenceConclusions
Higher P _max was independently associated with higher in-hospital mortality in mechanically ventilated critically ill patients under mechanical ventilatory support for reasons other than ARDS. Trial Registration ClinicalTrials.gov (NCT01868321).Liens article
©2018 The Author(s)